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Program
Tuesday 24th
14.00-19.00h. Registration Mercure Hotel Nancy Gare Place de la Gare, Nancy (Front of the Central Railway Station)
18:00-20:45. Welcome ceremony Art Museum, Stanislas Square
18:00-18:20. Welcome words: The Mayor of Nancy, Mathieu Klein or her/his Representative The Dean of the Medical Faculty, Stephane Zuily Jacques Delarue, President of SFN, Rosa-Maria Guéant-Rodriguez and Carine Pourié 18:20-18:20. Inaugural keynote lectures. Session chairs: David Alpers, J Mason and Jean-Louis Guéant 18:20-19:00. Irwin Rosenberg, Tufts University, Boston, USA, “My personal journey in Nutrition, homocysteine and related vitamins” 19:00-19:40. Helen McNulty, Ulster University Coleraine, Northern Ireland, “Role of one-carbon metabolism, B vitamins and related gene-nutrient interaction in determining blood pressure: can precision nutrition reduce the risk of hypertension?” 19:40-20:00. Tributes to John Sean Brosnan (), Jean-Luc Daval (Jean-Louis Guéant), Kilmer McCully (Irwin Rosenberg) and Hieronim Jakubowki (Joanna Perla-Kajan) 19:40-20:45. Cocktail
Wednesday 25th Medical Faculty, Campus Santé, Avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy
Session 1. 9.00-10.45. One Carbon metabolism (1CM), vitamins B and homocysteine associations with cardiovascular risk, stroke and blood pressure Chairs: Irwin Rosenberg and Stephane Zuily 9:00-9:25. Hieronim Jakubowki† and Lukasz Witucki, Rutgers University, Newark, NJ, USA and Poznań University of Life Sciences, Poznań, Poland “Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular Disease” †in memoriam 9:25-9:50. Stephane Zuily, Université de Lorraine, Nancy, France, “Management of Hyperhomocysteinemia in patients with thrombophilic disorders: the experience of the CHRU Nancy Referral Center” 9:50-10:15. Angela Devlin, University of British Columbian Vancouver, Canada, “Understanding the role of riboflavin in vascular function” 10:15-10:45. 2 short talks
coffee break
Session 2. 11:00-13:10. B vitamins and 1CM influence in Developmental Origins of Health and Disease Chairs: Julia Finkelstein and Michelle Murphy 11:00-11:25. Michelle Murphy, Universitat Rovira i Virgili, Reus, Spain, “Do maternal folate and cobalamin status play a role in development and health in the offspring, beyond neural tube development? Facts and gaps” 11.25-11:50. Julia Finkelstein, Cornell University, Ithaca, USA, “Periconceptional Vitamin B12 in one-carbon metabolism and maternal and child health” 11:50-12:15. Chittaranjan Yajnik, King Edwards Memorial Hospital Research Centre, Pune, India, “B-vitamins, 1-C metabolism and Developmental Origins of Health and Disease (DOHaD)” 12:15-12:40. Rosa-Maria Guéant-Rodriguez, University of Lorraine, Nancy, France, “One-carbon metabolism and epigenomic crosstalk in the prediction of child metabolic syndrome outcomes: data from the mother-child Eden cohort” 12:40-13:10. 2 short talks
Lunch
Session 3. 14:10-16:45. Modulating the transulfuration and remethylation pathways in health and diseases Chairs: Csaba Szabo and Viktor Közich 14:10-14:35. Csaba Szabo, University of Freibourg, Freibourg, Switzerland, “Impairment of cellular bioenergetics in Down syndrome" 14:35-15:00. Yann Herault, IGBMC/Université de Strasbourg, Strasbourg, France, “The trans-sulfuration pathway: the lessons from animal models of Down syndrome” 15:00-15:25. Viktor Közich, Charles University, Prague, Czech Republic, “Long term outcome in CBS deficiency: role of early detection by newborn screening” 15:25-15:50. Warren Kruger, Fox Chase Cancer Center, Philadelphia, USA, “Filaments or Tetramers? Studies on CBS Quaternary Structure” 15:50-16:15. Clotilde Mircher, Institut Jerome Lejeune, Paris, and Jean-Louis Guéant, Université de Lorraine, Nancy, France, “1CM/epigome/genome effects of thyroid hormone and/or folinic acid supplementations in the phase 3 ACTHYF trial in young children with Down syndrome” 16:15-16:30. 1 short talk
Parallel session #1. 1CM, B vitamins and the host-microbiota cross-talk Chairs: Martin Warren and Almut Heinken 14:10-14:35. Martin Warren, Quadram Institute and University of Kent, Norwich, UK. 14:35-15:00. Almut Heinken, Université de Lorraine, Nancy, France, “Modeling the 1CM and vitamin B metabolism in the microbiota” 15:00-15:25. Tunay Kokten, Université de Lorraine, Nancy, France, “The influence of the microbiota in the gut-brain axis in a rat model with methyl donor deficient diet” 15:25-15:50. Ramia Safar. Université de Lorraine, Nancy, France, “The effect of pectine supplementation on 1CM intestinal mucosa and microbiota in rat” 15:50-16:30. 2 short talks and 1 flash presentation
Coffee break
Poster session #1 and Flash presentations. 17:00-18:00. Chair session and prize committee Natalia Krupenko and Andrew McCaddon
19:00-20:00, Concert Hugues Leclère City hall, Stanislas Square
Thursday 26th Medical Faculty, Campus Santé, Avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy
Session 4. 9.00-10.45.1CM and B Vitamins in organ development and brain diseases Chairs: Nichola Greene and Ed Quadros 9:00-9:25. Ari Green, University of California, San Francisco, CA, USA, "Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults” 9:25-9:50. Nichola Greene, University college of London, London, UK, “Requirement for folate and one-carbon metabolism during pre-natal development of the brain” 9:50-10:15. Elise Pourié, Université de Lorraine, Nancy, France, “Influence of 1CM in pathomechanisms of Hungtington disease” 10:15-10:30. Vincent Ramaeckers, Liège, Belgium, “Clinical aspects of Cerebral Folate Deficiency syndrome’ 10:30-10:45. selected short talk
Coffee break
Session 5. 11:00-13:05. Inherited disorders of one carbon metabolism Chairs: Sean Froese and Carlo Dionisi 11:00-11:25. Sean Froese, University of Zurich, Zurich, Switzerland, “Inherited disorders of one carbon metabolism: lessons from multi-omic studies” 11.25-11:50. Carlo Dionisi, Bambino Jesu, Roma, Italy, "CblC defect: newborn screening, novel treatment modalities and lessons from untargeted metabolomic studies" 11:50-12:15. Martina Huemer, University of Zurich, Zurich, Switzerland, “inherited disorders of the remethylation pathway: revised Guidelines from the EHOD European network” 12:15-12:40. Karim Matmat, Université de Lorraine et Université de Strasbourg, Nancy et Strasbourg, France, “SIRT1 is a therapeutic target of brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism” 12:40-13:00. selected short talk and flash talk
Lunch
Session 6. 14:00-16:00. Coenzymes B and metabolic and cellular homeostasis Chairs: Carole Linster and Beatrice Morio 14:00-14:25. Carole Linster, University of Luxembourg, Luxembourg, “A New Function of CLYBL Bridging Metabolite Repair and Vitamin B12 Homeostasis” 14:25-14:50. Beatrice Morio, Inrae et Université de Lyon1, Lyon, France, "The crosstalk between mitochondrial dynamics and homeostasis of the one-carbon metabolism homeostasis: lessons from a mouse model of liver steatosis" 14:50-15:15. Serguei Krupenko, UNC, Chapel Hill, USA, “Delineation of the phenotypic and metabolomic profile of ALDH1L2-related neurodevelopmental disorder” 15:15-16h00. 3 selected short talks
Parallel session #2. ICM and vitamins B in health and diseases: lessons from organoids and cell and animal models Chairs: Carine Bossenmeyer Pourié and Joel Mason 14:00-14:25. Kostas Zarbalis, UC Davis, Davis, USA, “Excess folic acid supply alters proliferations and neurogenesis of cerebral cortical neural progenitors” 14:25-14:50. Carine Bossenmeyer Pourié, Université de Lorraine, Nancy, France, “Protein homocysteinylation in Alzheimer disease” 14:50-15:15. Gregory Pourié, Université de Lorraine, Nancy, France, "Altered Neurofunctionnal plasticity related to key target neuron proteins in rodent models with impaired one carbon metabolism" 15:15-16:00. 3 selected short talks
Coffee break
Poster session #2. Flash presentations. 16:15-17:15. Chair session and prize committee Natalia Krupenko and Andrew McCaddon
18:00-19:00. Commented visit of the Stanislas Square and medieval city
20:00-23:00. Gala Dinner City hall, Stanislas Square
Friday 27th Medical Faculty, Campus Santé, Avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy
Session 7. 9.00-10.45. ICM and B vitamins in aging: the lessons of population studies and clinical trials. Chairs: Mary Ward and Josh Miller 9:00-9:25. Mary Ward, Ulster University, Coleraine, Northern Ireland, “B-vitamins and bone health: current evidence from observational studies and randomised controlled trials” 9:25-9:50. Josh Miller, Rutgers, The State University of New Jersey, New Brunswick, USA, “Why is Lowering Elevated Homocysteine with B Vitamin Supplements Not Standard Clinical Practice for Prevention of Age-Related Cognitive Decline and Dementia?” 9:50-10:15. Luciana Hannibal, University of Freiburg, Freiburg, Germany, “Vitamin B12 Status and Supplementation in Plant-Based Diets” 10:15-10:45. 2 selected short talks
Coffee break
Session 8. 11:00-13:00. Round Table: Guidelines and Expert’s practice in diagnosis, management and treatment of vitamin B12 and folate deficiencies Chairs: Ralph Green and Jean-Louis Guéant 11:00-11:50. Willemina Rietsema, Emmanuel Andres, Ebba Nexo, Andrew Klein, Jean-Louis Guéant (10 minutes each) 11:50-12:30. Debate chaired by Ralph Green, Andrew McCaddon and Jean-Louis Guéant
12:30 -12-45. Concluding the Conference: Mary Ward, Ed Quadros and JL Guéant |
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