|
|
|
Program
Tuesday 24th
14.00-19.00h. Registration Mercure Hotel Nancy Gare Place de la Gare, Nancy (Front of the Central Railway Station)
17:30-20:15. Welcome ceremony University Hall of Honour, Library of the Faculty of Law, Economics and Management, Place Carnot, Nancy Centre, (Salon d'honneur de l'Université, Bibiothèque de la Faculté de Droit, Sciences Economiques et Gestion, Place Carnot, Nancy Centre) 17:30-17:50. Welcome words: The Mayor of Nancy, Mathieu Klein or her/his Representative The Representative of the Dean of the Medical Faculty, Stephane Zuily, President of the Scientific committee of the Medical Faculty, Abderrahim Oussalah The President of SFN, Jacques Delarue, and Rosa-Maria Guéant-Rodriguez and Carine Pourié, co-chairs of the Conference 17:50-18:20. Inaugural keynote lectures. Session chairs: David Alpers, J Mason and Jean-Louis Guéant 17:50-18:30. Irwin Rosenberg, Tufts University, Boston, USA, “My personal journey in Nutrition, homocysteine and related vitamins” 18:30-19:10. Helen McNulty, Ulster University Coleraine, Northern Ireland, “Role of one-carbon metabolism, B vitamins and related gene-nutrient interaction in determining blood pressure: can precision nutrition reduce the risk of hypertension?” 19:10-19:30. Tributes to John Sean Brosnan (Josh Miller and Ralph Green), Jean-Luc Daval (Jean-Louis Guéant), Kilmer McCully (Irwin Rosenberg) and Hieronim Jakubowki (Joanna Perla-Kajan) 19:30-20:15. Cocktail
Wednesday 25th Medical Faculty, Campus Santé, Avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy Session 1. 9.00-10.45. One Carbon metabolism (1CM), B-vitamins and homocysteine associations with blood pressure, stroke and cardiovascular risk Chairs: Irwin Rosenberg and Stephane Zuily 9:00-9:25. Hieronim Jakubowski† and Lukasz Witucki, Rutgers University, Newark, NJ, USA and Poznań University of Life Sciences, Poznań, Poland “Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular Disease” †in memoriam 9:25-9:50. Stephane Zuily, Université de Lorraine, Nancy, France, “Management of Hyperhomocysteinemia in patients with thrombophilic disorders: the experience of the CHRU Nancy Referral Center” 9:50-10:15. Angela Devlin, University of British Columbian Vancouver, Canada, “Understanding the role of riboflavin in vascular function” 10:15-10:45. Selected oral presentations - Joseph Orenuga, Ulster University, Coleraine, Northern Ireland, UK, Intervention with riboflavin improves vascular health and endothelial functioning in adults with the MTHFR TT genotype (The Intervene study) - Gina Roslan/Joshua Miller, Rutgers University, New Brunswick, NJ, USA, Conjunctival microvascular abnormalities, cerebrovascular white matter hyperintensity, and homocysteine in cognitively impaired older adults: A case-control study
coffee break
Session 2. 11:00-13:10. B vitamins and 1CM influence in Developmental Origins of Health and Disease Chairs: Julia Finkelstein and Michelle Murphy 11:00-11:25. Michelle Murphy, Universitat Rovira i Virgili, Reus, Spain, “Do maternal folate and cobalamin status play a role in development and health in the offspring, beyond neural tube development? Facts and gaps” 11.25-11:50. Julia Finkelstein, Cornell University, Ithaca, USA, “Periconceptional Vitamin B12 in one-carbon metabolism and maternal and child health” 11:50-12:15. Chittaranjan Yajnik, King Edwards Memorial Hospital Research Centre, Pune, India, “B-vitamins, 1-C metabolism and Developmental Origins of Health and Disease (DOHaD)” 12:15-12:40. Rosa-Maria Guéant-Rodriguez, University of Lorraine, Nancy, France, “One-carbon metabolism and epigenomic crosstalk in the prediction of child metabolic syndrome outcomes: data from the mother-child Eden cohort” 12:40-13:10. Selected oral presentations - Erika Castaño-Moreno, Tecnologico de Monterrey, Monterrey, Mexico Transcriptional disruption of one-carbon metabolism in obesity - Carolyn Ledowsky, University of Technology, Sydney, Australia, What are the effects of excess folic acid intake and blood folate concentrations in preconception and pregnancy
Lunch. Visiting poster exhibition
Session 3. 14:10-16:45. Modulating the transulfuration and remethylation pathways in health and diseases Chairs: Csaba Szabo and Viktor Közich 14:10-14:35. Csaba Szabo, University of Freibourg, Freibourg, Switzerland, “Impairment of cellular bioenergetics in Down syndrome" 14:35-15:00. Yann Herault, IGBMC/Université de Strasbourg, Strasbourg, France, “The trans-sulfuration pathway: the lessons from animal models of Down syndrome” 15:00-15:25. Viktor Közich, Charles University, Prague, Czech Republic, “Long term outcome in CBS deficiency: role of early detection by newborn screening” 15:25-15:50. Warren Kruger, Fox Chase Cancer Center, Philadelphia, USA, “Filaments or Tetramers? Studies on CBS Quaternary Structure” 15:50-16:15. Clotilde Mircher, Institut Jerome Lejeune, Paris, and Jean-Louis Guéant, Université de Lorraine, Nancy, France, “1CM/epigenome/genome effects of thyroid hormone and/or folinic acid supplementations in the phase 3 ACTHYF trial in young children with Down syndrome” 16:15-16:30. Selected oral presentation - Tomas Majtan, University of Fribourg, Fribourg, Switzerland, Identification and characterization of pharmacological chaperones of CBS
Parallel session #1. ICM and vitamins B in health and diseases: lessons from organoids and cell and animal models Chairs: Carine Bossenmeyer Pourié and Joel Mason 14:00-14:25. Kostas Zarbalis, UC Davis, Davis, USA, “Excess folic acid supply alters proliferations and neurogenesis of cerebral cortical neural progenitors” 14:25-14:50. Mathilde Renaud, Carine Bossenmeyer Pourié, Université de Lorraine, Nancy, France, “Protein homocysteinylation in Alzheimer disease” 14:50-15:15. Gregory Pourié, Université de Lorraine, Nancy, France, "Altered Neurofunctional plasticity related to key target neuron proteins in rodent models with impaired one carbon metabolism" 15:15-16:00. Selected oral presentations - Beata Vekeriotaite, University Children’s Hospital, University of Zurich, Switzerland Cerebral organoids as an in vitro model of remethylation disorders - Coralie Bergeron, The University of British Columbia, Vancouver, Canada, Characterizing the role of riboflavin in glucose homeostasis in an adolescent mouse mode - Joanna Perła-Kaján, Poznań University of Life Sciences, Poznan, Poland, Protein N-homocysteinylation in 5xFAD mouse model of Alzheimer’s disease with paraoxonase 1 deficiency
Coffee break
Extended session 2 Chairs: Julia Finkelstein and Michelle Murphy 16:15-17:45. Selected oral presentations - Zoe Lofft, The University of British Columbia, Vancouver, Canada, High folic acid impacts insulin-producing beta-cell function - Soumen Konar, Université de Lorraine, Nancy, France, Integration of placental multi-omics from EDEN reveals insights into early-life obesity programming - Albert Salas Huetos, Universitat Rovira i Virgili, Reus, Spain, Folate and cobalamin status and sperm quality in males of reproductive age: The Led-Fertyl study - Amy Tan, The University of British Columbia, Vancouver, Canada, A systematic review comparing pregnancy folate status between countries - Samuel Stanowski, Charles University, Prague, Czech Republic, Vitamin B12 status in pregnant Czech women - Luis A Santos-Calderón, Universitat Rovira i Virgili, Reus, Spain, Interaction between genetic polymorphisms affecting the roles of folate and cobalamin in methionine synthesis, is associated with adverse foetal outcome: The Reus-Tarragona Birth Cohort. 17:45-17:50. Selected flash presentation. - Beate Solvik, Innlandet Hopsital Trust, Lillehammer, Norway, Global summary of infant vitamin B12 status and deficiency – preliminary results from a systematic review and meta-analysis 17:50-17:55. Presentation of CluB12: Julian Owen
18:30-20:00, Concert Hugues Leclère City hall, Stanislas Square
Thursday 26th Medical Faculty, Campus Santé, Avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy Session 4. 9.00-10.45.1CM and B Vitamins in organ development and brain diseases Chairs: Nichola Greene and Ed Quadros 9:00-9:25. Ari Green, University of California, San Francisco, CA, USA, "Vitamin B12 levels association with functional and structural biomarkers of central nervous system injury in older adults” 9:25-9:50. Nichola Greene, University college of London, London, UK, “Requirement for folate and one-carbon metabolism during pre-natal development of the brain” 9:50-10:15. Elise Pourié, Université de Lorraine, Nancy, France, “Influence of 1CM in pathomechanisms of Hungtington disease” 10:15-10:45. Selected oral presentations - Douglas Ferreira, Newcastle University, Newcastle upon Tyne, UK, Structural insights into protein complexes involved in intracellular vitamin B12 metabolism - Chloe Santos, University College London, London, UK, Folate-resistant neural tube defects in glycine decarboxylase-deficient embryos
Coffee break
Session 5. 11:00-13:05. Inherited disorders of one carbon metabolism Chairs: Sean Froese and Carlo Dionisi 11:00-11:25. Sean Froese, University of Zurich, Zurich, Switzerland, “Inherited disorders of one carbon metabolism: lessons from multi-omic studies” 11.25-11:50. Carlo Dionisi, Bambino Jesu, Roma, Italy, "CblC defect: newborn screening, novel treatment modalities and lessons from untargeted metabolomic studies" 11:50-12:15. Martina Huemer, University of Zurich, Zurich, Switzerland, “inherited disorders of the remethylation pathway: revised Guidelines from the EHOD European network” 12:15-12:40. Karim Matmat, Université de Lorraine et Université de Strasbourg, Nancy et Strasbourg, France, “SIRT1 is a therapeutic target of brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism” 12:40-13:00. Selected oral presentation - Kit Yi Leung, University College London, London, UK, AAV-mediated gene therapy for non-ketotic hyperglycinemia
Lunch. Visiting poster exhibition
Session 6. 14:00-16:00. Coenzymes B and metabolic and cellular homeostasis Chairs: Carole Linster and Beatrice Morio 14:00-14:25. Carole Linster, University of Luxembourg, Luxembourg, “A New Function of CLYBL Bridging Metabolite Repair and Vitamin B12 Homeostasis” 14:25-14:50. Beatrice Morio, Inrae et Université de Lyon1, Lyon, France, "The crosstalk between mitochondrial dynamics and homeostasis of the one-carbon metabolism homeostasis: lessons from a mouse model of liver steatosis" 14:50-15:15. Serguey Krupenko, UNC, Chapel Hill, USA, “Delineation of the phenotypic and metabolomic profile of ALDH1L2-related neurodevelopmental disorder” 15:15-16h00. Selected oral presentations - Xia Gao, Baylor College of Medicine, Houston, Texas, USA, Phenylalanine determines adipocyte differentiation and lipogenesis via vitamin B6 metabolism - Guillaume Zoulim, University of Claude Bernard Lyon, Lyon, France, Betaine controls mitochondria-associated membrane integrity in the liver - Najme Seyekatouli, Université du Luxembourg, Luxembourg, Grand Duché de Luxembourg, Failure to repair damaged NAD(P)H disrupts serine and 1-carbon metabolism
Parallel session #2. 1CM, B vitamins, metabolic modeling host-microbiota, gene and environmental cross-talk Chairs: Martin Warren and Almut Heinken 14:00-14:25. Martin Warren, Quadram Institute and University of Kent, Norwich, UK “The battle for B12: cobamide competition and cooperation in the anaerobic gut microbiome”. 14:25-14:50. Almut Heinken, Université de Lorraine, Nancy, France, “Modeling the 1CM and vitamin B metabolism in the microbiota” 14:50-15:15. Tunay Kokten, Université de Lorraine, Nancy, France, “The influence of the microbiota in the gut-brain axis in a rat model with methyl donor deficient diet” 15:15-15:30. Ramia Safar, Université de Lorraine, Nancy, France, “The effect of pectine supplementation on 1CM intestinal mucosa and microbiota in rat” 15:30-16:15. Selected oral presentations - Sergey Fedosov, Aarhus University, Denmark, Uptake and the whole body balance of ingested vitamin B12 - Jordi Roma, Université de Lorraine, Nancy, France, Sirtuin 1 integrates dietary cues into genome-scale metabolic regulation through continuous modeling of gene expression - Lukasz Mencel, Poznań University of Life Sciences, Poznań, Poland, Hcy, Hcy-thiolactone, N-Hcy-proteins and deficiency of bleomycin hydrolase affect amyloid-β precursor protein processing
Coffee break
Session Flash presentations. 16:30-17:10. Chair session and prize committee Natalia Krupenko and Andrew McCaddon - Maud Fertig, Université de Lorraine, Nancy, France, Synergistic effects of gestational folate deficiency and exposure - Amina Doudou-Tellai, Université de Lorraine, Nancy, France, Interplay of m6A methylation and RNA binding proteins in hepatocarcinoma cells - Vito Ricardo Tomaso Zanotelli, University of Zurich, Zurich, Switzerland, Profiling of a large IEM sample collection to establish accurate diagnosis - Carolyn Ledowsky, University of Technology, Sydney, Australia, The impact of folate forms in prenatal multivitamins on recurrent pregnancy loss - Carolyn Ledowsky, University of Technology, Sydney, Australia, Knowledge and perceptions of folate prescribing amongst fertility Doctors - Sophie L Haggerwood, Ulster University Coleraine, Northern Ireland, B-vitamin status and cognitive function in relation to area-level socioeconomic deprivation: findings from the TUDA ageing study - Mayuri Bhosale, Poznań University of Life Sciences, Poznan, Poland, Disrupted homocysteine metabolism and Blmh deficiency promote ER Stress, UPR dysregulation, and apoptosis in mouse neuroblastoma N2a-APPSwe cell model of Alzheimer’s disease - Joanna Suszyńska-Zajczyk, Poznań University of Life Sciences, Poznan, Poland, Diet-induced hyperhomocysteinemia remodels the hypothalamic-ovarian axis: integrated spatial transcriptomics and single-cell profiling 17:10-17:15. Presentation of Biochimie, a journal published by Elsevier: Claude Forest, Editor
18:00-19:00. Commented visit of the Stanislas Square and Unesco world patrimony of the city
20:00-23:00. Gala Dinner City hall, Stanislas Square
Friday 27th Medical Faculty, Campus Santé, Avenue de la Forêt de Haye, Vandoeuvre-lès-Nancy Session 7. 9.00-10.45. ICM and B vitamins: the lessons of population studies and clinical trials. Chairs: Mary Ward and Josh Miller 9:00-9:25. Mary Ward, Ulster University, Coleraine, Northern Ireland, “B-vitamins and bone health: current evidence from observational studies and randomised controlled trials” 9:25-9:50. Josh Miller, Rutgers, The State University of New Jersey, New Brunswick, USA, “Why is lowering elevated homocysteine with B Vitamin supplements not standard clinical practice for prevention of age-related cognitive decline and dementia?” 9:50-10:15. Luciana Hannibal, University of Freiburg, Freiburg, Germany, “Vitamin B12 Status and Supplementation in Plant-Based Diets” 10:15-11:00. Selected oral presentations - Paul Jacques, Tufts University, Boston, USA, Vitamin B12 status and dementia incidence in the Framingham Heart Study: : impact of elevated folate status - Agata Sobczyńska-Malefora, King’s College London, London, UK, The prevalence of low and high folate status in adult patients attending primary and secondary care - Shane Gordon, Ulster University Coleraine, Northern Ireland, Associations of one-carbon metabolism, related B-vitamins and APOE genotype
Coffee break
Session 8. 11:15-13:00 Round Table: Guidelines and Expert’s practice in diagnosis, management and treatment of vitamin B12 and folate deficiencies Chairs: Ralph Green and Jean-Louis Guéant 11:15-12:15. Willemina Rietsema, Andrew Klein, Ebba Nexo, Jean-Louis Guéant (15 minutes each) 12:15-13:00. Debate chaired by Ralph Green, Andrew McCaddon and Jean-Louis Guéant
13:00 -13.15. Concluding the Conference: Mary Ward, Ed Quadros and JL Guéant |
